probably only use for background too specific
- PURPOSE OF THIS STUDY- "The purpose of this study is to evaluate the phenotypic responses of human anterior cruciate ligament (ACL) cells on two biodegradable materials: poly(
-caprolactone) (PCL) and chitosan" - CHITOSAN- "Chitosan is a deacetylated product of chitin that is a plentiful polysaccharide found in nature and is safe for the human body. It was reported that this material could accelerate the wound healing and stimulate the macrophage releasing lots of growth factors to promote ECM production"
- PCL- "poly(-caprolactone) (PCL) is a synthetic and semi-crystalline linear
-polyester and has been used as an implantable material for a long time." - FDA APPROVED- "Both PCL and chitosan are biodegradable and have been approved by Food and Drug Administration (FDA)"
- bad results for chitosan adhesion, better for PCL specific numbers in article- "After 4 h of adhesion, cell number on PCL (48,800 � 4100) and chitosan (17,900 � 5300) showed a significant difference... After incubation for 3 days, cell growth was observed on both substrates. The cell number on PCL and chitosan increased to 91,100 � 16,700 and 29,000 � 4100, respectively" (the symbol thing is plus or minus)
- NEED- "Therefore, a substrate with the activity to promote cell adhesion and ECM production is very valuable."
- SUPPORT CHITOSAN AS SCAFFOLD- "These results support the chitosan as scaffold for ACL tissue engineering, which can stimulate ACL cells to synthesize more quantity of FN and TGF
1 proteins."
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